• Posted October 3, 2024

Antibodies in Mom's Breast Milk Are Protecting Babies

THURSDAY, Oct. 3, 2024 (HeathDay News) -- Moms-to-be have long known about breast milk's multiple benefits. Now, a global study confirms that antibodies passed from to baby in breast milk can indeed shield against disease.

Immune system antibodies against one common infection, rotavirus, were especially protective, said a team from the University of Rochester in New York.

“It was encouraging to see such a clear link between higher antibody levels and a delay to rotavirus infection," said study lead author Dr. Kirsi Jarvinen-Seppo, a professor of allergy and immunology at the university's Golisano Children’s Hospital.

The new study was funded by the Bill and Melinda Gates Foundation and published recently in the Journal of Clinical Investigation.

The research involved analysis of breast milk samples from 695 women in Finland, the United States, Pakistan, Peru and Bangladesh.

Jarvinen-Seppo and her colleagues measured levels of certain IgA and IgG immune system antibodies produced in breast milk, and pitted them against 1,607 proteins from 30 disease-linked germs.

The participants' global diversity was key to the research.

“We would expect to find differences in antibody levels in different countries, due to different diseases circulating among areas of the world, but this is one of the first times that there’s been a head-to-head comparison for dozens of pathogens across several continents,” Jarvinen-Seppo explained in a university news release.

The study found that breast milk from moms containing high levels of the IgA and IgG immune system antibodies appeared linked to a baby's ability to fend off rotavirus, which can trigger severe and sometimes life-threatening diarrhea.

Moms living in lower-income nations typically had even higher levels of protective antibodies in their breast milk compared to women from richer countries, the researchers noted.

That was particularly true for antibodies against the germs that cause Shigella and pneumococcus, two major causes of illness and death to babies and children in poor countries.

There was one unexpected finding: Women who were overweight or obese tended to have lower levels of protective antibodies in their breast milk, compared to normal-weight women.

That was counterintuitive, Jarvinen-Seppo said.

“We had anticipated that underweight mothers might have lower antibody levels due to poorer nutritional status,” she said. “Due to rising obesity rates worldwide, this could be a significant finding, but this is preliminary and additional research is needed since this is the first time this has been measured.”

More information

Find out more about the benefits of breastfeeding at the March of Dimes.

SOURCE: University of Buffalo, news release, Oct. 1, 2024